L. Kollar et al., THE TOPICAL TREATMENT OF INFUSION THROMBOPHLEBITIS WITH PENTOSAN POLYSULFATE SODIUM OINTMENT - A RANDOMIZED DOUBLE-BLIND-STUDY, Perfusion, 6(12), 1993, pp. 470
In a 7 day randomised double-blind trial, the equivalence of efficacy
of pentosan polysulfate sodium ointment (PPS ointment, 0.5%) in compar
ison to mucopolysaccharide ointment (MPS ointment, 0.445%) was studied
in 110 adult stationary patients suffering from acute infusion thromb
ophlebitis in one arm. The study medication was applied three times da
ily. Antithrombotic and antiinflammatory efficacy were evaluated by da
ily monitoring of the severity of the symptoms (induration, swelling,
erythema, temperature, pain) as defined by scores on a rive-stage scal
e. In addition, I-125-fibrinogen was injected on the day before the on
set of treatment and radioactivity was measured over the inflamed vein
s on day 1, 3 and 7 of the treatment period. All patients concluded th
e treatment according to the protocol. Both ointments reduced the radi
oactivity in the thrombus and the global severity of symptoms to 50% a
fter 3 days. By day 7 most patients had recovered completely from the
inflammation. Thus, both ointments were equivalent in their efficacy.
However, the symptom attenuation with the pentosan polysulfate sodium
ointment appeared to be somewhat faster and, since this formulation is
prepared from plant origin, this preparation was free from any risk o
f BSE infection. No adverse events were reported and the treatment was
well tolerated by all patients.