LAMBERT-EATON MYASTHENIC SYNDROME-ASSOCIATED WITH SJOGRENS-SYNDROME AND DISCOID LUPUS-ERYTHEMATOSUS

A 65-year-old woman with facial erythema and hypergammmaglobulinemia d eveloped excessive fatigability. A diagnosis of Lambert-Eaton myasthen ic syndrome (LEMS) was made from electrophysiological studies. She had symptoms and laboratory data compatible with probable Sjogren's syndr ome. Skin biopsy revealed the histological findings of discoid lupus e rythematosus. Treatment with 3,4-diaminopyridine resulted in the impro vement of fatigability. LEMS should be recognized as a treatable compl ication of systemic autoimmune diseases.