BIOAVAILABILITY OF IBUPROFEN FROM HARD GELATIN CAPSULES CONTAINING DIFFERENT VISCOSITY GRADES OF HYDROXYPROPYLMETHYLCELLULOSE AND SODIUM CARBOXYMETHYLCELLULOSE
S. Ojantakanen et al., BIOAVAILABILITY OF IBUPROFEN FROM HARD GELATIN CAPSULES CONTAINING DIFFERENT VISCOSITY GRADES OF HYDROXYPROPYLMETHYLCELLULOSE AND SODIUM CARBOXYMETHYLCELLULOSE, European journal of pharmaceutical sciences, 1(2), 1993, pp. 109-114
The effect of viscosity grade (molecular weight group) of the polymer
diluent on the bioavailability of ibuprofen from hard gelatin capsules
was evaluated in two single-dose (400 mg) cross-over studies in healt
hy volunteers following an overnight fast. The polymers studied were n
onionic hydroxypropylmethylcellulose (HPMC) K100 and K15M, and anionic
sodium carboxymethylcellulose (NaCMC) LV, MV and HV. Plain ibuprofen
capsules were used for reference. Use of HPMC K15M led to markedly sus
tained drug absorption from the capsules. The t(max) and C(max) values
differed significantly (P < 0.001) from the reference values. The sus
taining effect of the lower viscosity grade, K100, was less pronounced
. NaCMC-based capsules exhibited sustained-release properties similar
to those of the HPMC K100 capsules. In the case of NaCMC, the molecula
r weight of the polymer had no significant effect on drug absorption.
No differences in the extent of bioavailability of ibuprofen between t
he formulations studied were evident.