PRACTICAL PALLADIUM-MEDIATED DEPROTECTIVE METHOD OF ALLYLOXYCARBONYL IN AQUEOUS-MEDIA

The Allyloxycarbonyl (Alloc) moiety can be removed smoothly and select ively in good yield (73-100%) from allylic eaters, carbamates and carb onates by aqueous Pd (0) catalyzed allyl transfer to diethylamine in a queous media employing a water soluble phosphine. The allyl scavenger as well as by product allyl diethylamine are volatile and easily remov ed in vacuo. In a two phase system an increased selectivity is seen. T he method has been successfully used for deprotection of a wide range of secondary amines or base sensitive derivatives and the catalyst is efficiently recycled.