ASSEMBLY OF ALZHEIMER-LIKE FILAMENTS FROM FULL-LENGTH TAU-PROTEIN

Authors
CROWTHER RA OLESEN OF SMITH MJ JAKES R GOEDERT M
Citation
Ra. Crowther et al., ASSEMBLY OF ALZHEIMER-LIKE FILAMENTS FROM FULL-LENGTH TAU-PROTEIN, FEBS letters, 337(2), 1994, pp. 135-138
Citations number
33
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
337
Issue
2
Year of publication
1994
Pages
135 - 138
Database
ISI
SICI code
0014-5793(1994)337:2<135:AOAFFF>2.0.ZU;2-#
Abstract
The principal fibrous component of neurofibrillary pathology in Alzhei mer's disease, the paired helical filament, is formed from hyperphosph orylated microtubule-associated protein tau. Here we show that recombi nant tan protein either in a non-phosphorylated state or following pho sphorylation with brain extract can be assembled in vitro into filamen ts resembling those seen in Alzheimer's disease.