REMARKABLE ENHANCEMENT OF BINDING-AFFINITY OF HETEROCYCLE-MODIFIED DNA TO DNA AND RNA - SYNTHESIS, CHARACTERIZATION AND BIOPHYSICAL EVALUATION OF N-2-IMIDAZOLYLPROPYLGUANINE AND N-2-IMIDAZOLYLPROPYL-2-AMINOADENINE MODIFIED OLIGONUCLEOTIDES

Authors
RAMASAMY KS ZOUNES M GONZALEZ C FREIER SM LESNIK EA CUMMINS LL GRIFFEY RH MONIA BP COOK PD
Citation
Ks. Ramasamy et al., REMARKABLE ENHANCEMENT OF BINDING-AFFINITY OF HETEROCYCLE-MODIFIED DNA TO DNA AND RNA - SYNTHESIS, CHARACTERIZATION AND BIOPHYSICAL EVALUATION OF N-2-IMIDAZOLYLPROPYLGUANINE AND N-2-IMIDAZOLYLPROPYL-2-AMINOADENINE MODIFIED OLIGONUCLEOTIDES, Tetrahedron letters, 35(2), 1994, pp. 215-218
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
2
Year of publication
1994
Pages
215 - 218
Database
ISI
SICI code
0040-4039(1994)35:2<215:REOBOH>2.0.ZU;2-E
Abstract
Oligonucleotides containing novel N-2-Imidazolylpropylguanine and N-2- Imidazolylpropyl-2-aminoadenine moieties were synthesized and studied for their hybridization and biophysical properties. Interestingly, the se heterocycle modified oligonucleotides showed a remarkable enhanceme nt of heteroduplex binding affinity when hybridized to complementary D NA.