A NEW SYNTHESIS OF RHEIN

Authors
GALLAGHER PT HICKS TA LIGHTFOOT AP OWTON WM
Citation
Pt. Gallagher et al., A NEW SYNTHESIS OF RHEIN, Tetrahedron letters, 35(2), 1994, pp. 289-292
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
2
Year of publication
1994
Pages
289 - 292
Database
ISI
SICI code
0040-4039(1994)35:2<289:ANSOR>2.0.ZU;2-Z
Abstract
A novel synthesis of Rhein (2), the active metabolite of the anti-oste oarthritic drug Diacetyl Rhein (1) has been achieved. Key steps includ e stereospecific olefination of aldehyde 21 with novel phosphonate 28 and the cyclisation of acid 31 to produce anthracene 32.