OLIGODEOXYNUCLEOTIDES CONTAINING O-2-ALKYLTHYMINE - SYNTHESIS AND CHARACTERIZATION

Authors
XU YZ SWANN PF
Citation
Yz. Xu et Pf. Swann, OLIGODEOXYNUCLEOTIDES CONTAINING O-2-ALKYLTHYMINE - SYNTHESIS AND CHARACTERIZATION, Tetrahedron letters, 35(2), 1994, pp. 303-306
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
2
Year of publication
1994
Pages
303 - 306
Database
ISI
SICI code
0040-4039(1994)35:2<303:OCO-SA>2.0.ZU;2-6
Abstract
simple procedures for preparation of O-2-alkylthymidines and of their phosphoramidite monomers (IV) are described. These monomers have been successfully incorporated into DNA oligomers. The measurements of the melting temperature (Tm) of DNA duplexes show that O-2-methylthymine p referentially pairs with guanine rather than with adenine.