NOVEL POLYENE CYCLIZATION ROUTES TO THE ACYL TETRONIC ACID IONOPHORE TETRONASIN (ICI M139603)

Authors
BOONS GJ LENNON IC LEY SV OWEN ESE STAUNTON J WADSWORTH DJ
Citation
Gj. Boons et al., NOVEL POLYENE CYCLIZATION ROUTES TO THE ACYL TETRONIC ACID IONOPHORE TETRONASIN (ICI M139603), Tetrahedron letters, 35(2), 1994, pp. 323-326
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
2
Year of publication
1994
Pages
323 - 326
Database
ISI
SICI code
0040-4039(1994)35:2<323:NPCRTT>2.0.ZU;2-H
Abstract
An approach to the total synthesis of the ionophore antibiotic tetrona sin (I) is reported, in which the key step is a novel base catalysed c ascade cyslisation of an activated polyene (2). This establishes two r ings and four stereogenic centres in one step. A related polyene (16) has been cyclised in a similar fashion, illustrating the generality of the procedure.