AVERMECTIN BIOSYSTHESIS - INTACT INCORPORATION OF A DIKETIDE CHAIN-ASSEMBLY INTERMEDIATE INTO THE POLYKETIDE MACROCYCLIC RING

Authors
DUTTON CJ HOOPER AM LEADLAY PF STAUNTON J
Citation
Cj. Dutton et al., AVERMECTIN BIOSYSTHESIS - INTACT INCORPORATION OF A DIKETIDE CHAIN-ASSEMBLY INTERMEDIATE INTO THE POLYKETIDE MACROCYCLIC RING, Tetrahedron letters, 35(2), 1994, pp. 327-330
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
2
Year of publication
1994
Pages
327 - 330
Database
ISI
SICI code
0040-4039(1994)35:2<327:AB-IIO>2.0.ZU;2-N
Abstract
Incorporation experiments in Streptomyces avermitilis with synthetic a nalogues of the proposed diketide intermediate support the processive mechanism of chain assembly in the biosynthesis of the polyketide core of the avermectin structure. Specific incorporation of a C-13 labelle d precursor was established by C-13 NMR; intact incorporation of two d euterium-labelled analogues was established by electrospray mass spect rometry (ESMS).