IMMUNE-RESPONSE TO HUMAN PAPILLOMAVIRUS TYPE-16 E6 GENE IN A LIVE VACCINIA VECTOR

Authors
GAO L CHAIN B SINCLAIR C CRAWFORD L ZHOU J MORRIS J ZHU X STAUSS H
Citation
L. Gao et al., IMMUNE-RESPONSE TO HUMAN PAPILLOMAVIRUS TYPE-16 E6 GENE IN A LIVE VACCINIA VECTOR, Journal of General Virology, 75, 1994, pp. 157-164
Citations number
29
Categorie Soggetti
Virology
Journal title
Journal of General Virology → ACNP
ISSN journal
00221317
Volume
75
Year of publication
1994
Part
1
Pages
157 - 164
Database
ISI
SICI code
0022-1317(1994)75:<157:ITHPTE>2.0.ZU;2-2
Abstract
Immunization of mice with a recombinant vaccinia virus expressing the human papillomavirus type 16 (HPV-16) E6 gene elicits specific antibod y, proliferative and cytotoxic T lymphocyte responses. T and B cell ep itopes were mapped by using synthetic peptides. This study provides th e background to future investigation aimed at developing prophylactic and therapeutic vaccines against HPV-16 infection and cervical cancer.