Am. Lessells et al., OBSERVER VARIABILITY IN THE HISTOPATHOLOGICAL REPORTING OF ABNORMAL RECTAL BIOPSY SPECIMENS, Journal of Clinical Pathology, 47(1), 1994, pp. 48-52
Aims-To study the consistency of reporting of abnormal rectal biopsy s
pecimens, especially in the differentiation of inflammatory bowel dise
ase from other causes of abnormality. Methods-Sixty rectal biopsy spec
imens were identified from patients presenting with bloody diarrhoea.
These were then circulated to the 11 consultant pathologists in the st
udy who filled in a proforma with a List of 12 diagnostic categories a
nd 22 features. Results-Forty one of the 60 cases were examples of inf
lammatory bowel disease. In 33 of these cases nine or more pathologist
s had made the diagnosis. Further categorisation into ulcerative colit
is and Crohn's disease showed better recognition of ulcerative colitis
. In the 19 cases of non-inflammatory bowel disease recognition of pse
udomembranous colitis and solitary rectal ulcer syndrome was good, but
the results were poorer in the case of infective colitis. Conclusion-
The findings suggest that a group of consultant pathologists can diffe
rentiate between inflammatory bowel disease and other causes of an abn
ormal rectal biopsy specimen and can also recognise pseudomembranous c
olitis and solitary rectal ulcer syndrome satisfactorily.