M. Kozempel et al., SIMULATED SCALE-UP AND COST ESTIMATE OF A PROCESS FOR ALKALINE ISOMERIZATION OF LACTOSE TO LACTULOSE USING BORIC-ACID AS COMPLEXATION AGENT, Journal of chemical technology and biotechnology, 68(2), 1997, pp. 229-235
A continuous pilot plant process for converting lactose to lactulose,
using boric acid as a complexation agent was previously developed. To
appraise the commercial feasibility of the process, a scale-up to a co
mmercial plant using the ERRC Food Process Simulator, a process simula
tor developed at the Eastern Regional Research Center was projected an
d a cost estimate made. The cost to produce a 55% lactulose syrup at a
rate of 93 kilograms per hour (563 359 kg year(-1)) was $5.20 per kil
ogram ($2.36 per pound). These costs, which do not include packaging o
r distribution expenses, do include a 25% return on the plant investme
nt.