IMMUNOSUPPRESSIVE ACTIVITY OF SERA OF PREGNANT-WOMEN AN CYTOTOXIC T-LYMPHOCYTE-MEDIATED CYTOLYSIS .1. CHARACTERIZATION OF THE ACTIVE FRACTION

Authors
LETELLIER C FIZET D BALTZ T VEZON G
Citation
C. Letellier et al., IMMUNOSUPPRESSIVE ACTIVITY OF SERA OF PREGNANT-WOMEN AN CYTOTOXIC T-LYMPHOCYTE-MEDIATED CYTOLYSIS .1. CHARACTERIZATION OF THE ACTIVE FRACTION, Gynecologic and obstetric investigation, 37(1), 1994, pp. 1-5
Citations number
23
Categorie Soggetti
Obsetric & Gynecology
Journal title
Gynecologic and obstetric investigation → ACNP
ISSN journal
03787346
Volume
37
Issue
1
Year of publication
1994
Pages
1 - 5
Database
ISI
SICI code
0378-7346(1994)37:1<1:IAOSOP>2.0.ZU;2-V
Abstract
Sera of healthy pregnant women have a nonspecific inhibitory activity on the specific cytolytic activity of activated cytotoxic T lymphocyte s in vitro. The serum fraction of pregnant females which is responsibl e for this activity has been characterized. The equivalent fraction de rived from sera of healthy men has a similar but reduced activity comp ared with the female fraction. This suppressive factor seems to be act ivated during pregnancy. Moreover, this study sheds some light an the reasons behind the attenuation of the maternal immune system during pr egnancy.