DOSE TITRATION, AND OPEN 6-WEEK EFFICACY AND SAFETY STUDY OF DESMOPRESSIN TABLETS IN MANAGEMENT OF NOCTURNAL ENURESIS

The efficacy and safety of 6 weeks of treatment with desmopressin tabl ets at doses of 200 to 400 mu g. at bedtime were investigated in 33 ch ildren with monosymptomatic nocturnal enuresis. During an initial 1 to 2-week dose titration period 22 patients (67%) became either complete ly dry or showed improvement, 7 (21%) showed no response and 4 (12%) d ropped out of therapy. During tablet treatment 17 patients on 400 mu g . and 5 on 200 mu g. at bedtime increased the number of weekly dry nig hts from 2.0 +/- 1.6 (standard deviation) during a 2-week observation period to 5.2 +/- 1.9 (p <0.001). During a subsequent 2-week period 40 mu g. intranasal desmopressin showed a similar overall efficacy, with a mean of 5.4 +/- 1.6 dry nights per week. In addition, intranasal tr eatment was able to increase the number of dry nights in 2 of the 7 no nresponders to tablet treatment.