Si. Rajfer, PERSPECTIVE OF THE PHARMACEUTICAL-INDUSTRY ON THE DEVELOPMENT OF NEW DRUGS FOR HEART-FAILURE, Journal of the American College of Cardiology, 22(4), 1993, pp. 10000198-10000200
Despite recent therapeutic advances, patients with heart failure have
considerable morbidity and a markedly shortened life span. The prevale
nce of heart failure increases with age and is the most common cause o
f hospital admission in the elderly. In developing innovative remedies
for this disorder, the scientific challenges, regulatory agencies' gu
idelines, physician behavior and marketing requirements must be consid
ered.