SYNTHESIS OF CHIRAL N-PROTECTED BETA-AMINO ALCOHOLS BY THE USE OF UNCAS

Authors
FEHRENTZ JA CALIFANO JC AMBLARD M MARTINEZ J LOFFET A
Citation
Ja. Fehrentz et al., SYNTHESIS OF CHIRAL N-PROTECTED BETA-AMINO ALCOHOLS BY THE USE OF UNCAS, Tetrahedron letters, 35(4), 1994, pp. 569-571
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
4
Year of publication
1994
Pages
569 - 571
Database
ISI
SICI code
0040-4039(1994)35:4<569:SOCNBA>2.0.ZU;2-6
Abstract
A facile synthesis of a wide variety of N-protected beta-amino alcohol derivatives under mild conditions is described. N-urethane protected amino acid N-carboxyanhydrides (UNCAs) were used as starting material and reduced into the corresponding alcohols with the appropriate hydri de, sodium borohydride. The reaction is simple, unexpensive, easily sc aled up, and proceeds without observable racemization.