PHOTOINDUCED DNA CLEAVAGE BY DESIGNED MOLECULES WITH CONJUGATED ENE-YNE-KETENE FUNCTIONALITIES

Authors
NAKATANI K ISOE S MAEKAWA S SAITO I
Citation
K. Nakatani et al., PHOTOINDUCED DNA CLEAVAGE BY DESIGNED MOLECULES WITH CONJUGATED ENE-YNE-KETENE FUNCTIONALITIES, Tetrahedron letters, 35(4), 1994, pp. 605-608
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
4
Year of publication
1994
Pages
605 - 608
Database
ISI
SICI code
0040-4039(1994)35:4<605:PDCBDM>2.0.ZU;2-O
Abstract
Upon photoirradiation, diazoketone 1 was found to induce single strand cleavage of plasmid pBR322 DNA at concentration of 100 mu M. Conjugat e ene-yne moiety was essential for DNA-cleaving activities.