The repeated sequence TTAGGG is present at all tested vertebrate telom
eres including those of humans and at the telomeres of evolutionarily
very distant organisms such as trypanosomes and slime moulds. We teste
d for the presence of this sequence in the genome of the crustacean is
opod Asellus aquaticus. Fluorescence in situ hybridization and BAL31 n
uclease digestion demonstrate that the (TTAGGG)(n) sequence occurs at
the extreme termini of the chromosomes and also at an interstitial sit
e.