DIAGNOSTIC APPLICATIONS OF SIMULTANEOUSLY ACQUIRED DUAL-ISOTOPE SINGLE-PHOTON EMISSION CT SCANS

Citation
D. Mathews et al., DIAGNOSTIC APPLICATIONS OF SIMULTANEOUSLY ACQUIRED DUAL-ISOTOPE SINGLE-PHOTON EMISSION CT SCANS, American journal of neuroradiology, 15(1), 1994, pp. 63-71
Citations number
18
Categorie Soggetti
Neurosciences,"Radiology,Nuclear Medicine & Medical Imaging
ISSN journal
01956108
Volume
15
Issue
1
Year of publication
1994
Pages
63 - 71
Database
ISI
SICI code
0195-6108(1994)15:1<63:DAOSAD>2.0.ZU;2-A
Abstract
PURPOSE: To report the development and validation of a technique of du al tracer single-photon emission CT brain imaging using technetium-99m hexamethyl-propyteneamine oxime and iodine-223 iodoamphetamine agents and the application of this technique in patients with a variety of d iagnoses. METHODS: Contamination between the two isotopes' energy wind ows was calculated by opening both energy windows while scanning a gro up of patients using a single isotope. To compare uniformity of I-123 down-scatter, Tc-99m studies were performed both before and after the administration of I-123 in five of 24 dual studies. The 24 patients st udied with the dual-isotope technique were evaluated during acetazolam ide testing, trial balloon occlusion, or embolization of an arterioven ous malformation. RESULTS: In a dual acquisition, average count contam ination of an I-223 study by Tc-99m was less than 1% of the total I-12 3 counts, and contamination of a Tc-99m study by I-123 was approximate ly 12% of the total Tc-99m counts. Tc-99m studies performed both befor e and after the administration of I-123 demonstrated that contaminatin g counts do not adversely affect scan interpretation. Dual-tracer scan s were completed in all 24 patients, 10 of whom showed changes after i ntervention. CONCLUSIONS: Dual-tracer single-photon emission CT brain scans of adequate diagnostic quality are possible using Tc-99m and I-1 23.