D. Mathews et al., DIAGNOSTIC APPLICATIONS OF SIMULTANEOUSLY ACQUIRED DUAL-ISOTOPE SINGLE-PHOTON EMISSION CT SCANS, American journal of neuroradiology, 15(1), 1994, pp. 63-71
Citations number
18
Categorie Soggetti
Neurosciences,"Radiology,Nuclear Medicine & Medical Imaging
PURPOSE: To report the development and validation of a technique of du
al tracer single-photon emission CT brain imaging using technetium-99m
hexamethyl-propyteneamine oxime and iodine-223 iodoamphetamine agents
and the application of this technique in patients with a variety of d
iagnoses. METHODS: Contamination between the two isotopes' energy wind
ows was calculated by opening both energy windows while scanning a gro
up of patients using a single isotope. To compare uniformity of I-123
down-scatter, Tc-99m studies were performed both before and after the
administration of I-123 in five of 24 dual studies. The 24 patients st
udied with the dual-isotope technique were evaluated during acetazolam
ide testing, trial balloon occlusion, or embolization of an arterioven
ous malformation. RESULTS: In a dual acquisition, average count contam
ination of an I-223 study by Tc-99m was less than 1% of the total I-12
3 counts, and contamination of a Tc-99m study by I-123 was approximate
ly 12% of the total Tc-99m counts. Tc-99m studies performed both befor
e and after the administration of I-123 demonstrated that contaminatin
g counts do not adversely affect scan interpretation. Dual-tracer scan
s were completed in all 24 patients, 10 of whom showed changes after i
ntervention. CONCLUSIONS: Dual-tracer single-photon emission CT brain
scans of adequate diagnostic quality are possible using Tc-99m and I-1
23.