C. Utas et al., CONTROL OF PLASMA-GLUCOSE WITH SOMATOSTATIN ANALOG (SMS 201-995) DURING SURGICAL REMOVAL OF INSULINOMAS, Postgraduate medical journal, 69(818), 1993, pp. 920-921
Prevention of hypoglycaemia may sometimes be difficult in the operativ
e period of insulinoma when parenteral volume overload is contraindica
ted due to severe cardiac failure. We investigated the effects of octr
eotide on hypoglycaemia during operations in two patients with insulin
oma, one of whom had severe congestive heart failure. We found no hypo
glycaemic values by using octreotide 100 mu g administered subcutaneou
sly one hour before surgery. Octreotide therapy can safely be used bef
ore surgery to prevent hypoglycaemia in patients with insulinoma.