EFFECTS OF ACID-INHIBITORY ANTIULCER DRUGS ON MUCIN BIOSYNTHESIS IN THE RAT STOMACH

The effects of the anti-acid secretory agents, cimetidine hyl-1H-imida zol-4-yl)methyl]thio)ethyl)guanidine), ranitidine thio)ethyl)-N'-methy l-2-nitro-1,1-ethene-diamine), roxatidine -[m-(1-piperidinylmethyl)phe noxy]-propyl)acetamide hydrochloride), FRG-8813 inomethyl)-2-pyridyl]o xy-(z)-2-butenyl)acetamide), omeprazole (5-methoxy-2-([(4-methoxy-3,5 methylpyridinyl)methyl]sulfinyl)-1H-benzimidazole) and NC-1300-O-3 tyl methylamino)benzyl]sulfinyl)-1H-benzimidazole), on mucin biosynthesis were studied in rat gastric mucosa by using an organ culture technique . [H-3]Glucosamine incorporation was stimulated in the corpus region b y the histamine H-2 receptor antagonists which have a six-membered aro matic ring, roxatidine and FRG-8813, and the new H+,K+-ATPase inhibito r, NC-1300-O-3. Thus, these drugs not only inhibit acid secretion but may also promote gastric mucosal protective actions. The present obser vations also demonstrate that the determination of mucin biosynthesis may be a useful tool for evaluation of mucosal protective activity.