The rivers flowing through the Amazon Basin are both physically and ch
emically heterogeneous. Through detailed geochemical analyses, variabi
lity is shown to be primarily controlled by both substrate lithology i
n the source region and soil geochemistry in the erosional regime. The
solute-rich waters of the Rio Solimoes reflect the drainage from the
Andes Mountains and the fertility of the varzea. In contrast, the solu
te-deficient waters of the Rio Negro reflect the infertility of the la
teritic and podsolitic terrains of the Central Amazon. Rivers flowing
through the Precambrian Shield have an intermediate composition. Such
observations suggest that it is possible to classify the chemical comp
osition of Amazonian rivers according to the soil types in their catch
ment regions and vice versa. These findings have profound implications
for using water chemistry as an indicator of the agricultural and min
eral potential of a region. Results from this study also confirm that
precipitation is a significant source of major cations and trace metal
s to solute-deficient river systems such as the Rio Negro.