ISOANCISTROCLADINE FROM ANCISTROCLADUS-HEYNEANUS - THE FIRST NATURALLY-OCCURRING N-UNSUBSTITUTED CIS-CONFIGURATED NAPHTHYLTETRAHYDROISOQUINOLINE ALKALOID
G. Bringmann et al., ISOANCISTROCLADINE FROM ANCISTROCLADUS-HEYNEANUS - THE FIRST NATURALLY-OCCURRING N-UNSUBSTITUTED CIS-CONFIGURATED NAPHTHYLTETRAHYDROISOQUINOLINE ALKALOID, Phytochemistry, 35(1), 1994, pp. 259-261
The isolation and structure elucidation of isoancistrocladine, a novel
naphthylisoquinoline alkaloid from the roots of Ancistrocladus heynea
nus, is described. The structural attribution was greatly facilitated
by the fact that isoancistrocladine had already been prepared before,
by reduction of the natural product ancistrocladinine. Isoancistroclad
ine is the first naturally occurring naphthylisoquinoline alkaloid tha
t has a relative cis-configuration at C-1 versus C-3 without being met
hylated on the nitrogen.