MYOCARDIAL-ISCHEMIA AFTER 5-FLUOROURACIL CHEMOTHERAPY

Authors
RASTOGI N CHAG M AYYAGARI S
Citation
N. Rastogi et al., MYOCARDIAL-ISCHEMIA AFTER 5-FLUOROURACIL CHEMOTHERAPY, International journal of cardiology, 42(3), 1993, pp. 285-287
Citations number
5
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
International journal of cardiology → ACNP
ISSN journal
01675273
Volume
42
Issue
3
Year of publication
1993
Pages
285 - 287
Database
ISI
SICI code
0167-5273(1993)42:3<285:MA5C>2.0.ZU;2-T
Abstract
A 40-year-old male patient with carcinoma of the tonsil was put on a 5 -fluorouracil and cisplatinum regimen. On day 2 during 5-fluorouracil infusion, he had features of myocardial ischemia manifesting as angina and ST-elevation in ECG. These vasospastic ischemic changes subsided after nitroglycerine plus nifedipine therapy. Such vasospastic toxicit y of 5-fluorouracil is rare and few such cases have been reported.