K. Bugra et al., AFGF, BFGF AND FLG MESSENGER-RNAS SHOW DISTINCT PATTERNS OF INDUCTIONIN THE HIPPOCAMPUS FOLLOWING KAINATE-INDUCED SEIZURES, European journal of neuroscience, 6(1), 1994, pp. 58-66
We report that kainic acid-induced seizures lead to marked increases i
n mRNAs encoding basic and acidic fibroblast growth factors (bFGF and
aFGF, respectively) and flg, one of their receptors, in the rat hippoc
ampus. Anticonvulsant pretreatment inhibits the up-regulation of these
mRNAs. The observed increase in flg mRNA levels involves the pyramida
l cells of all hippocampal subfietds and the granular cells of the den
tate gyrus. The increased expression of aFGF and bFGF mRNAs is limited
to neuron populations that are resistant to seizure-induced injury, t
he granular cells of dentate gyrus and pyramidal cells of CA1 region,
respectively. The results suggest that the increase in the FGFs and fl
g may play pivotal roles in neuron survival and in long-term changes o
ccurring in the hippocampus following seizure activity.