AFGF, BFGF AND FLG MESSENGER-RNAS SHOW DISTINCT PATTERNS OF INDUCTIONIN THE HIPPOCAMPUS FOLLOWING KAINATE-INDUCED SEIZURES

Citation
K. Bugra et al., AFGF, BFGF AND FLG MESSENGER-RNAS SHOW DISTINCT PATTERNS OF INDUCTIONIN THE HIPPOCAMPUS FOLLOWING KAINATE-INDUCED SEIZURES, European journal of neuroscience, 6(1), 1994, pp. 58-66
Citations number
93
Categorie Soggetti
Neurosciences
ISSN journal
0953816X
Volume
6
Issue
1
Year of publication
1994
Pages
58 - 66
Database
ISI
SICI code
0953-816X(1994)6:1<58:ABAFMS>2.0.ZU;2-H
Abstract
We report that kainic acid-induced seizures lead to marked increases i n mRNAs encoding basic and acidic fibroblast growth factors (bFGF and aFGF, respectively) and flg, one of their receptors, in the rat hippoc ampus. Anticonvulsant pretreatment inhibits the up-regulation of these mRNAs. The observed increase in flg mRNA levels involves the pyramida l cells of all hippocampal subfietds and the granular cells of the den tate gyrus. The increased expression of aFGF and bFGF mRNAs is limited to neuron populations that are resistant to seizure-induced injury, t he granular cells of dentate gyrus and pyramidal cells of CA1 region, respectively. The results suggest that the increase in the FGFs and fl g may play pivotal roles in neuron survival and in long-term changes o ccurring in the hippocampus following seizure activity.