Subungual keratoacanthomas (SKA) differ in clinical presentation, biol
ogical behaviour and the therapy needed from keratoacanthomas in other
localizations. Against the backdrop of two personal observations and
a review of the literature, the authors describe clinical and histolog
ical features and also the differential diagnosis and therapy and this
rare benign neoplasm. Patients present with a rapidly growing, painfu
l subungual mass, which causes destruction of the underlying bone and
usually does not regress spontaneously. Histological differentiation f
rom squamous cell carcinoma is essential as the prognosis and treatmen
t are different. SKA is treated by local excision and curettage. Erosi
ons of the underlying distal phalanx usually heal spontaneously. Howev
er, persistent recurrences after subtotal excision often necessitate a
mputation of the distal phalanx.