PARTIAL DEFICIENCY OF THYROXINE-BINDING GLOBULIN - AN HLA STUDY

Authors
HNIKOVA O IVASKOVA E KRACMAR P KUPKOVA L SAJDLOVA H ZIKMUND J
Citation
O. Hnikova et al., PARTIAL DEFICIENCY OF THYROXINE-BINDING GLOBULIN - AN HLA STUDY, Hormone research, 40(5-6), 1993, pp. 201-203
Citations number
15
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Hormone research → ACNP
ISSN journal
03010163
Volume
40
Issue
5-6
Year of publication
1993
Pages
201 - 203
Database
ISI
SICI code
0301-0163(1993)40:5-6<201:PDOTG->2.0.ZU;2-X
Abstract
Partial thyroxine-binding globulin (TBG) deficiency, with a median TBG of 2.3 mg/l, was found in 25 mature babies with hypothyroxinaemia (3 girls and 22 boys) from our screening programme for congenital hypothy roidism during 1988-1990. Analysis of the HLA system revealed the poss ibility that antigen DR6 may be considered as a risk factor for TBG de ficiency (44.0 vs. 19.2%) and DR2 as a protective factor (16.0 vs. 37. 5%). Similar laboratory findings were also present in 16 mothers and 1 father.