COMPUTER MODELING OF THE INTERACTION BETWEEN HUMAN CHORIOGONADOTROPINAND ITS RECEPTOR

Primary structural homology between the hormone binding site of the LH /CG receptor and the enzyme binding site of chymotrypsin inhibitor has been identified. This has led to the application of a knowledge-based approach of molecular modelling to describe the interaction of chorio gonadotropin (CG) with the LH/CG receptor. A tertiary structural model for the mode of recognition between the hormone and the receptor has been proposed. As in other such processes at the molecular level, the recognition between CG and its receptor is mediated through non-covale nt interactions. The specificity of recognition is achieved by complem entarity in van der Waals surfaces, hydrogen bonding and non-polar ass ociations. The model shows nine hydrogen bonds between the hormone and the receptor involving polar side chains as well as backbone amine an d carbonyl groups. A hydrophobic cluster involving side chain groups a t the interface is also important in stabilization of the intermolecul ar interactions.