A CONVENIENT SOLID-PHASE PREPARATION OF PEPTIDE SUBSTITUTED AMIDES

Authors
VOYER N LAVOIE A PINETTE M BERNIER J
Citation
N. Voyer et al., A CONVENIENT SOLID-PHASE PREPARATION OF PEPTIDE SUBSTITUTED AMIDES, Tetrahedron letters, 35(3), 1994, pp. 355-358
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
3
Year of publication
1994
Pages
355 - 358
Database
ISI
SICI code
0040-4039(1994)35:3<355:ACSPOP>2.0.ZU;2-R
Abstract
The preparation of the title compounds by a solid phase procedure is r eported. The method involves the incorporation of different amines at the C-terminal position of a peptide molecule by its nucleophilic disp lacement from the oxime resin. The method works well with primary alip hatic and aromatic amines but gives lower yields with deactivated or s terically hindered amines.