A FACILE SYNTHESIS OF OPTICALLY-ACTIVE C-2-SYMMETRICAL 2,5-DISUBSTITUTED PYRROLIDINES AND OTHER BETA,BETA'-DIHYDROXYAMINES

Authors
KOH K BEN RN DURST T
Citation
K. Koh et al., A FACILE SYNTHESIS OF OPTICALLY-ACTIVE C-2-SYMMETRICAL 2,5-DISUBSTITUTED PYRROLIDINES AND OTHER BETA,BETA'-DIHYDROXYAMINES, Tetrahedron letters, 35(3), 1994, pp. 375-378
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
3
Year of publication
1994
Pages
375 - 378
Database
ISI
SICI code
0040-4039(1994)35:3<375:AFSOOC>2.0.ZU;2-H
Abstract
2,5-Dibromoadipic acid has been converted into the di-(R)-pantolactone ester of (S,S)-pyyrolidine-2,5-dicarboxylic acid in two steps. This c ompound serves ar a precursor to C-2-symmetric 2,5-disubstituted pyrro lidines. The synthesis of linear C-2-symmetric beta,beta'-dihydroxyami nes starting with alpha-bromophenylacetic acid and (S)-phenylglycine e thyl ester is also reported.