SPECTROPHOTOMETRIC DETERMINATION OF KETOROLAC TROMETHAMINE BY CHARGE-TRANSFER AND ION-PAIR COMPLEXATION

Simple and sensitive spectrophotometric methods are described for the determination of ketorolac tromethamine based on charge-transfer and i on-pair complexation reactions. In the first method the drug was react ed with 2,3-dichloro-5,-dicyano-p-benzoquinone (DDQ) or with 2,4-dichl oro-6-nitrophenol (DCNP) in methanol. The colour formed due to the for mation of charge transfer complex showed maximum absorbance at 392 nm and 425 nm respectively and linearity in the range 10-80 mu g.ml(-1).I n the second method ketorolac tromethamine was treated with reagents, viz. methylene blue (MB) or safranine (SF), in the presence of phospha te buffer. The ion pair complexes were extracted into chloroform and t he absorbance was measured at 640 nm and 515 nm respectively. Beer's l aw was obeyed in the range of 5-50 mu g.ml(-1) with both the reagents.