HUMAN HEPATOCYTE NUCLEAR FACTOR-IV (HHNF4) GENE MAPS TO 20Q12-Q13.1 BETWEEN PLCGI AND D20S17

Authors
ARGYROKASTRITIS A KAMAKARI S KAPSETAKI M KRITIS A TALIANIDIS I MOSCHONAS NK
Citation
A. Argyrokastritis et al., HUMAN HEPATOCYTE NUCLEAR FACTOR-IV (HHNF4) GENE MAPS TO 20Q12-Q13.1 BETWEEN PLCGI AND D20S17, Human genetics, 99(2), 1997, pp. 233-236
Citations number
19
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
99
Issue
2
Year of publication
1997
Pages
233 - 236
Database
ISI
SICI code
0340-6717(1997)99:2<233:HHNF(G>2.0.ZU;2-K
Abstract
Human hepatocyte nuclear factor 4 (hHNF-4) is a member of the nuclear hormone receptor superfamily and an important transcription factor and developmental regulator of liver-specific genes. Distinct hHNF-4 cDNA s corresponding to various HNF-4 isoforms have been recently character ised. Three cDNAs, hHNF-4A, B and C, are considered splice variants of a single hHNF-4 gene. We have mapped hHNF-4 to 20q12-q13.1 between PL CG1 and D20S17 by genetic linkage analysis, taking advantage of an adj acent PstI restriction fragment length polymorphism, (RFLP), and by fl uorescence in situ hybridisation. hHFN-4 maps to chromosome 20 in a re gion syntenic with mouse chromosome 2 where the hnf-4 homologue has be en assigned.