4-ETHOXYAMPHETAMINE - EFFECTS ON INTRACRANIAL SELF-STIMULATION AND IN-VITRO UPTAKE AND RELEASE OF H-3 DOPAMINE AND H-3 SEROTONIN IN THE BRAINS OF RATS

Experiments were conducted to compare the effects of 4-ethoxyamphetami ne a novel ''designer'' amphetamine, with (+)-amphetamine and an earli er ''designer'' amphetamine, 4-methoxyamphetamine, on rats. (+)-Amphet amine significantly decreased frequency threshold measures in an intra cranial self-stimulation (ICSS) procedure using medial forebrain bundl e electrodes, while 4-methoxyamphetamine and 4-ethoxyamphetamine incre ased these ICSS frequency thresholds. 4-Methoxyamphetamine and 4-ethox yamphetamine had more potent effects on inhibition of uptake and stimu lation of spontaneous release of 5-hydroxytryptamine (serotonin) than of dopamine. It is concluded that the neuropsychopharmacological profi le of 4-ethoxyamphetamine is unlike that of (+)-amphetamine, but simil ar to that of 4-methoxyamphetamine, a potent hallucinogen in humans.