2,2'-DISUBSTITUTED BIPHENYLS - SYNTHESIS AND SUPPRESSIVE EFFECT AGAINST CARBON TETRACHLORIDE-INDUCED LIVER-INJURY

Authors
KONDO K TAKAHASHI M OHMIZU H MATSUMOTO M TAGUCHI I IWASAKI T
Citation
K. Kondo et al., 2,2'-DISUBSTITUTED BIPHENYLS - SYNTHESIS AND SUPPRESSIVE EFFECT AGAINST CARBON TETRACHLORIDE-INDUCED LIVER-INJURY, Chemical and Pharmaceutical Bulletin, 42(1), 1994, pp. 62-66
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
42
Issue
1
Year of publication
1994
Pages
62 - 66
Database
ISI
SICI code
0009-2363(1994)42:1<62:2B-SAS>2.0.ZU;2-#
Abstract
2,2'-Disubstituted biphenyl compounds (1-15) were synthesized by using the Ullmann coupling reaction as a keg step. The suppressive effect o f these compounds against CCl4-induced liver injuries in mice was eval uated. An unsymmetrical biphenyl (14f) exhibited the most potent activ ity. The structure-activity relationship is discussed.