S. Watano et al., EFFECTS OF OPERATIONAL VARIABLES ON THE PROPERTIES OF GRANULES PREPARED BY MOISTURE CONTROL METHOD IN TUMBLING FLUIDIZED-BED GRANULATION, Chemical and Pharmaceutical Bulletin, 42(1), 1994, pp. 133-137
Effects of operational variables such as liquid how rate, inlet air te
mperature and inlet air humidity on the properties of granules, prepar
ed by a tumbling fluidized bed granulation while controlling the moist
ure content with an IR moisture sensor, were investigated experimental
ly. As increase in the liquid how rate, i.e. the increase of the dropl
et size resulted in a slight increase of granule size and size distrib
ution, while little influence was found of the inlet air temperature a
nd humidity on granule size, size distribution or the apparent density
. Remarkably good reproducibility was obtained in the granules prepare
d by the moisture control method. It was therefore concluded that by a
pplying this method to the wet granulation by a type of fluidized bed,
the effects of external circumstances could be fully eliminated and g
ood reproducibility maintained.