STUDIES OF REACTIVE INORGANIC LAYERED COMPOUNDS WITH DRUGS .1. INTERCALATION OF PHOSPHATIDYLCHOLINE CONTAINING INDOMETHACIN INTO SYNTHETIC MICA

The interaction between a sodium-type synthetic mica (Na-TSM), a model material of reactive layered compounds, and phosphatidylcholine (PC) in a solid dispersion (IM-PC) with indomethacin (IM), a model drug, wa s investigated using X-rag diffraction analysis. It was found that IM- PC interacts with Na-TSM, and can be immobilized in the interlayer spa ce by means of heating. When IM mole fractions in IRI-PC increased fro m 0.25 to 0.5, the amount of IM intercalated into Na-TSM increased cor respondingly from 5-18%. Consequently, it was determined that inorgani c layered compounds, such as Na-TSM, intercalated with drugs in PC can be obtained.