All current optimization techniques in radiation therapy benefit from
the use of strongly non-uniform radiation beams. The most flexible way
of generating these fields under real time control is by elementary b
eam scanning and/or dynamic multileaf collimation. In this work genera
l analytical expressions are derived for the required motion of the co
llimator leaves to achieve a desired energy fluence distribution or co
llimator opening density in the patient in the shortest possible time.
By simplification of the general expressions the equations of motion
have been derived for both the shrinking field and the curtain shutter
techniques with the associated approximations clearly quantified. The
mechanical limitations on leaf motion, caused by the finite velocity
and acceleration, are taken into account. It is shown that almost any
desired energy fluence distribution can be created even when the limit
ations on velocity and acceleration are considered. The basic rule wit
h the curtain shutter technique is that when the energy fluence gradie
nt along the direction of motion of the leaves is positive, the leadin
g leaf should move at maximum speed and the lagging leaf should modula
te the field. In regions where the gradient is negative the lagging le
af should instead move at full speed and the leading leaf should modul
ate the field. The overall treatment time is then proportional to the
total increment in energy fluence or opening density between consecuti
ve minima and maxima. For energy fluence profiles with numerous high p
eaks the treatment time may therefore increase considerably over that
for conventional uniform dose delivery. However, in general the treatm
ent time is prolonged by a factor of about two compared to a tradition
al uniform treatment. Obviously the method developed here for multilea
f collimators is also suitable for simple block collimators since it c
an be used to deliver arbitrary regular or irregular 'dynamic wedge' p
rofiles along the direction of motion of the collimator blocks.