The aim of this study is to develop a model which computes exit dose v
alues from transmission dose data obtained during patient treatment wi
th an electronic portal imaging device (EPID). The proposed model conv
olves the primary dose distribution, derived from transmission dose di
stributions at large air gaps, with a scatter kernel to obtain the exi
t dose. The influence of inhomogeneities on the scatter contribution i
s taken into account by using a radiological path length model. To det
ermine the parameters of the model, an extensive set of transmission d
ose measurements was performed behind various phantoms in an 8 MV beam
using a liquid-filled EPID. The influence on the transmission dose of
field size, phantom thickness, air gap between phantom and detector,
and source-phantom distance was investigated. At air gaps larger than
50 cm the distribution of scattered dose is almost flat and its contri
bution to the total dose is relatively small, thus allowing an accurat
e separation of the primary and scattered dose by subtraction. Scatter
ed dose distributions for air gaps smaller than 50 cm were obtained by
subtracting the primary dose (corrected for divergence) from the meas
ured total transmission dose. The resulting scattered dose distributio
n behind homogeneous phantoms has a Gaussian shaped profile, which bec
omes wider with increasing air gap. The relative contribution of scatt
ered dose depends on the phantom thickness and is maximal for a thickn
ess of about 10 cm. Using these results, the parameters of the convolu
tion model (i.e., the shape of the scatter kernel) were determined. Wi
th the model the absolute exit dose is predicted with an accuracy of a
bout 2% (1 s.d.) within the entire radiation field for homogeneous pha
ntoms. Inhomogeneities are taken into account by calculating the radio
logical path length from the measured primary dose, i.e., without usin
g CT data. By using the measured radiological path length the exit dos
e can be determined for inhomogeneous phantoms with an accuracy of 2.5
%. It is concluded that, using our convolution model, EPID measurement
s at large air gaps can be used to estimate absolute exit doses in an
8 MV beam with an accuracy of 2.5%. (C) 1997 American Association of P
hysicists in Medicine.