CROSS-PROTECTION BETWEEN SPECIES OF THE SCHISTOSOMA-HAEMATOBIUM GROUPINDUCED BY VACCINATION WITH IRRADIATED PARASITES

Authors
NAVARRETE S ROLLINSON D AGNEW AM
Citation
S. Navarrete et al., CROSS-PROTECTION BETWEEN SPECIES OF THE SCHISTOSOMA-HAEMATOBIUM GROUPINDUCED BY VACCINATION WITH IRRADIATED PARASITES, Parasite immunology, 16(1), 1994, pp. 19-25
Citations number
36
Categorie Soggetti
Immunology,Parasitiology
Journal title
Parasite immunology → ACNP
ISSN journal
01419838
Volume
16
Issue
1
Year of publication
1994
Pages
19 - 25
Database
ISI
SICI code
0141-9838(1994)16:1<19:CBSOTS>2.0.ZU;2-O
Abstract
Mice vaccinated with irradiated cercaliae of Schistosoma haematobium, S. bovis and S. margrebowiei showed good levels of resistance (38-62%) against an homologous challenge, and varying degrees of resistance (1 9-46%), against challenges with closely related species. No protection against S. mansoni was induced by vaccination with any of these speci es. This restricted cross-protection reflects the close phylogenetic r elationship between species of the S. haematobium group and indicates that immunologically important epitopes are conserved within this spec ies complex.