PREPARATION OF TE-99M NITRIDO CORE BETA-DIKETONATE COMPLEXES FOR RADIOPHARMACEUTICALS

A series of neutral technetium-99m beta-diketonate radiopharmaceutical s containing the Tc = N group has been prepared in which the substitue nt of the beta-diketone ligand is varied to cause chemical changes in the resultant complexes. Analyses by TLC, HPLC, and paper electrophore sis show that the complexes are neutral, lipidsoluble tracers. Their i n-vitro properties, evaluated by means of octanol-water and cyclohexan e-water partition coefficients and protein binding determination, show a high lipophilic character which may give them potential as a brain imaging agent.