SYNERGISTIC INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)REPLICATION IN-VITRO BY SULFATED PARAMYLON AND 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE (AZT)

Authors
NAKASHIMA H OHSHIRO Y MIYANO N YAMAMOTO N ICHIKAWA S KONDO H TAKEDA M SAKAGAMI H
Citation
H. Nakashima et al., SYNERGISTIC INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)REPLICATION IN-VITRO BY SULFATED PARAMYLON AND 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE (AZT), Letters in applied microbiology, 18(1), 1994, pp. 24-26
Citations number
9
Categorie Soggetti
Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Letters in applied microbiology → ACNP
ISSN journal
02668254
Volume
18
Issue
1
Year of publication
1994
Pages
24 - 26
Database
ISI
SICI code
0266-8254(1994)18:1<24:SIOHT(>2.0.ZU;2-1
Abstract
A sulphated derivative of paramylon, a water-insoluble (1-3)-beta-D-gl ucan from Euglena gracilis, inhibited the cytopathic effect of human i mmunodeficiency virus (HIV-1) on cultured MT-4 cells as efficiently as dextran sulphate. A computer-assisted three-dimensional graphing tech nique revealed that paramylon sulphate and 3'-azido-2', 3'-dideoxythym idine (AZT) synergistically inhibited HIV replication.