The purpose of this investigation was to ellucidate the biology of dis
traction osteogenesis during mandibular widening. Midsymphyseal vertic
al interdental osteotomies were performed in nine Macaca mulatta monke
ys. After a latency period a tooth-borne appliance was activated at a
rate of 0.5 mm twice a day for 7-10 days. The appliance was then stabi
lized for a period of 4 or 8 weeks. The distraction gap at the inferio
r portion of the symphysis was bridged completely by new bony trabecul
ae. Bone formation in the interdental area was apparently related to t
he surgical technique. Newly formed bony trabeculae were oriented para
llel to the direction of distraction. The location of the osteotomy si
te with an adequate margin of alveolar bone contiguous with the adjace
nt teeth was necessary for the induction of the distraction osteogenes
is. Disproportional movement between superior and inferior portions of
the distracted segments was noted.