J. Lopez et al., ERYTHROPOIETIN IN THE TREATMENT OF DELAYED IMMUNE HEMOLYSIS OF A MAJOR ABO-INCOMPATIBLE BONE-MARROW TRANSPLANT, American journal of hematology, 45(3), 1994, pp. 237-239
Delayed immune hemolysis can be observed after major ABO-incompatible
bone marrow transplants (BMT). The management of these hemolytic episo
des includes transfusion of group O red blood cells and increases of i
mmunosuppression. Here we report the case of a as-year-old patient who
developed overt immune hemolysis on day +50 after a HLA-identical ABO
-incompatible BMT. To avoid added immunosuppression, erythropoietin wa
s started: an increase in reticulocytes sufficient to maintain hemoglo
bin despite persistent hemolysis was observed. We conclude that erythr
opoietin may have a role in the management of delayed-onset hemolysis
of major ABO-incompatible BMT, especially when added immunosuppression
is undesirable. (C) 1994 Wiley-Liss, Inc.