Jl. Larpent et al., THE USE OF GLYCERYL TRINITRATE IN INEXAMINABLE PATIENTS WITH ANAL-FISSURE, International journal of colorectal disease, 11(6), 1996, pp. 263-263
Increased anal canal pressure is often the cause of severe anal pain a
nd results in difficulty in performing anal examinations in patients w
ith anal fissure. Sublingual administration of glyceryl trinitrate (Na
tispray(R)) has been shown to reduce hypertonia of the internal sphinc
ter [1].