ANALYSIS OF HUMAN GROWTH-HORMONE GENE 5' SEQUENCES IN ISOLATED GROWTH-HORMONE DEFICIENCY PATIENTS

Authors
WANG YX YU LL SHENG Q MENG CW SUN J CHEN SS
Citation
Yx. Wang et al., ANALYSIS OF HUMAN GROWTH-HORMONE GENE 5' SEQUENCES IN ISOLATED GROWTH-HORMONE DEFICIENCY PATIENTS, Journal of Medical Genetics, 31(1), 1994, pp. 81-82
Citations number
8
Categorie Soggetti
Genetics & Heredity
Journal title
Journal of Medical Genetics → ACNP
ISSN journal
00222593
Volume
31
Issue
1
Year of publication
1994
Pages
81 - 82
Database
ISI
SICI code
0022-2593(1994)31:1<81:AOHGG5>2.0.ZU;2-O
Abstract
Human growth hormone (hGH) gene deletion (6.7 to 7.6 kb) is one of the causes of isolated growth hormone deficiency (IGHD), named IGHD IA. I GHD IA, however, only accounts for about 10% of the total IGHD patient s. Most IGHD is caused by unknown mechanisms. Here, hGH gene 5' sequen ces in three IGHD patients without hGH gene deletion were analysed to see if there was any mutation hindering the expression of the hGH gene .