SPATIAL PHASE DISCRIMINATION IN MONKEYS WITH EXPERIMENTAL STRABISMUS

Human strabismic amblyopes show deficits in spatial vision that are re vealed in a variety of visual tasks. In particular, they show severe d eficits in their ability to encode the relative spatial phase of the s inusoidal components in a compound grating. To investigate the neural basis of strabismic amblyopia we tested the ability of monkeys with ex perimentally induced strabismus to encode spatial phase relationships. First, we trained them to discriminate between compound gratings (mad e of a fundamental sinusoid and its third harmonic) that differed only in the relative phase of their components. These monkeys exhibited a pattern of severe deficits that resemble those described in the human population of strabismic amblyopes. We conclude that these animals rep resent a valid model of strabismic amblyopia. Second, we show that a m odel that had been used to account for the performance of normal human subjects and of humans with anisometropic amblyopia fails to predict the performance of monkeys with strabismic amblyopia.