Tj. Parry et Jg. Mcelligott, KAINIC ACID ADMINISTRATION IN THE FASTIGIAL NUCLEUS PRODUCES DIFFERENTIAL CARDIOVASCULAR EFFECTS IN AWAKE AND ANESTHETIZED RATS, Brain research, 635(1-2), 1994, pp. 27-36
Kainic acid was microinjected or microdialyzed into the rostral medial
aspect of the fastigial nucleus to determine its effect on mean arter
ial pressure and heart rate. This was carried out in both the awake an
d the anesthetized (alpha-chloralose) rat. In awake animals, kainic ac
id elicited an initial phasic presser response which was followed by a
long-term elevation of mean arterial pressure that lasted for the dur
ation of the experiment (2 h). Rats anesthetized with alpha-chloralose
exhibited only a tonic depressor response. This converted to a presse
r response as the rats began to emerge from anesthesia after 2 h. Both
the awake and the anesthetized rats exhibited regular phasic changes
in mean arterial pressure that was superimposed on the longer term cha
nges in the mean arterial pressure. Similar results were obtained in b
oth the microinjected and the microdialyzed animals. Thus, stimulation
of the intrinsic fastigial neurons by kainic acid evokes an elevation
of the mean arterial pressure in the awake rat. This is manifested as
a decrease in pressure in the anesthetized animal. Thus, stimulation
of the cardiovascular region of the fastigial nucleus can increase or
decrease mean arterial pressure. It is possible that the direction of
the change in mean arterial pressure is dependent on the level of intr
insic fastigial neural activity.