TRANSLOCATION OF CD3D GENE IN AN ACUTE MYELOID-LEUKEMIA (M5) WITH T(1117)(Q2321)

Cytogenetic studies in patients with acute leukemia showed structural abnormalities on chromosome 11 at band q23 in five cases. Four of thes e had acute lymphoblastic leukemia (ALL) associated with t(4;11)(q21;q 23) and one case had acute nonlymphoblastic leukemia (ANLL) (M5) assoc iated with t(11;17)(q23;q21). We examined the CD3D and c-ets-l genes i n the t(11;17)(q23;21) patient to ascertain any association between th em and the chromosome change. In situ hybridization results showed tha t unlike in other studied cases with rearrangements of 11q23, the CD3D gene in the t(11;17)(q23;21) is transposed to the der(17) chromosome, providing evidence for a different breakpoint in the 11q23 region.