Epidemic nosocomial infections are defined as hospital-acquired infect
ions that represent an increase in incidence over expected rates. Epid
emic-associated infections usually are clustered temporally or geograp
hically, suggesting that the infections are from a common source or ar
e secondary to increased person-to-person transmission. Epidemics are
important, because they account for a substantial percentage of nosoco
mial infections. Furthermore, if infection control personnel thoroughl
y investigate outbreaks of nosocomial infections, they may identify ne
w agents, reservoirs, or modes of transmission.